대한신장학회

논문분류	춘계학술대회 초록집
제목	The predictive role of serum triglyceride to high-density lipoprotein cholesterol ratio according to renal function in patients with acute myocardial infarction
저자	Jin Sug Kim*, Da Rae Kim, Su Woong Jung, Yu Ho Lee, Tae Won Lee, Chun Gyoo Ihm, Yang Gyun Kim , Sang Ho Lee, Ju Young Moon , Jong Shin Woo, Weon Kim, Kyung Hwan Jeong and Korea Acute Myocardial Infarction Registry Investigators
출판정보	2016; 2016(1):
키워드	major adverse cardiovascular events, renal dysfunction, triglyceride to HDL cholesterol ratio
초록	Background: High serum triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio has been reported as an independent predictor for cardiovascular events in the general population. However, the prognostic effect of the TG/HDL-C ratio on patients with renal dysfunction is unclear. We examined the association of TG/HDL-C ratio and major adverse cardiovascular events (MACEs) according to kidney function in patients with acute myocardial infarction (AMI). Methods: This study was based on a retrospective cohort, the Korea Acute Myocardial Infarction Registry (KAMIR) database. Among 13,897 patients who diagnosed AMI from November 2005 to July 2008, we studied 8,225 patients who had baseline TG/HDL-C ratio. Patients were stratified into three groups by estimated glomerular filtration (eGFR) and the TG/HDL-C ratio was categorized into tertiles based on the quantity of the study population and the distribution of TG/HDL-C ratio. We investigated the 12-month MACEs, including cardiac death, MI, and repeated percutaneous coronary intervention or coronary artery bypass grafting. Results: During 12-month follow up period, 686 patients (8.3%) had MACEs. The log-rank test identified a significant association between the TG/HDL-C ratio and MACEs (p<0.001) in the whole study cohort. In patients with normal renal function (eGFR≥90ml/min per 1.73 m2) and mildly reduced renal function (eGFR=60-89 ml/min per 1.73 m2), higher TG/HDL-C ratio was significantly associated with increased risk of MACEs (hazard ratio [HR] 1.65, 95% confidence interval [CI] 1.01-2.69, p=0.018; HR 1.46, 95% CI 1.06-1.99, p=0.02, respectively). However, in patients with moderately reduced renal function (eGFR<60 ml/min per 1.73 m2), higher TG/HDL-C ratio did not associated with increased risk of MACEs (HR 1.42, 95% CI 0.93-2.17, p=0.104). Conclusion: A higher serum TG/HDL-C ratio was an independent predictor for occurrence of MACEs in patients with normal and mildly reduced renal function. However, in patients with moderately reduced renal function, the TG/HDL-C ratio did not showed significant association with occurrence of MACEs.
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