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논문분류	춘계학술대회 초록집
제목	Calcium Channel Blockers And Contrast Induced Nephropathy: A Meta Analysis Of Randomized Controlled Trials
저자	Michelle ARDALES, *Frederick OGBAC
출판정보	2017; 2017(1):
키워드	Calcium Channel Blockers, Contrast Induced Nephropathy
초록	Objectives : To estimate the effectiveness of calcium channel blockers in preventing contrast nephropathy. Methods : Relevant studies published up to October 2016 that investigated the efficacy of calcium channel blockers for preventing CIN were collected from PUBMED, MEDLINE and Cochrane Central Register of Controlled Trials. The information was reviewed and extracted by two evaluators independently. The primary outcome was CIN. A fixed effect meta-analysis of RCT assessing the effects of calcium channel blocking drugs in preventing CIN fitting the inclusion criteria was conducted. Statistical analysis was performed by using Review Manager 5.3. Results : In the meta-analysis of the 3 trials, which included 395 randomized patients, the combined risk ratio was 0.50 (95% CI 0.23-1.09). This metaanalysis demonstrates a nonsignificant trend towards benefit in patients treated with calcium channel blockers. No significant heterogeneity was revealed among the identified comparison (Chi2 = 0.50, p 0.78, I2 0%). Conclusions : Calcium channel blockers may lower the risk of contrast induced nephropathy. Further randomized trials of large sample size will add importantly relevant information to the totality of evidence.
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