대한신장학회

논문분류	춘계학술대회 초록집
제목	Clinical Outcome of Kidney Re-transplantation in Comparison With First Kidney Transplantation in Korea; Nationwide Cohort Study
저자	Jeong Ho Kim* 1, 1, Tae Hyun Ban2, Tae Hyun Ban2, Bum Soon Choi2, Bum Soon Choi2, Cheol Whee Park2, Cheol Whee Park2, Chul Woo Yang2, Chul Woo Yang2, Yong-Soo Kim2, Yong-Soo Kim2, Byung Ha Chung2 and the Korean Organ Transplantation Registry Study Group
출판정보	2016; 2016(1):
키워드	Acute rejection, Allograft survival, Kidney re-transplantation, KOTRY
초록	Background: Due to the limitation of the survival of kidney allograft, increasing number of patients need to take re-transplantation (re-KT) after the first allograft failure. In this study, we investigated the clinical characteristics and clinical outcomes of re-KT recipients in comparison with those of first KT using nationwide registry. Methods: We retrospectively analyzed 4757 adult kidney transplant recipients registered in Korean organ transplantation registry database from 2009 to 2012. These cases were divided into 4 groups; first KT (n=2762) and re-KT (n=162) from living donor (LD), first KT (n=1647) and re-KT (n=186) from deceased donor (DD). We compared the clinical outcomes such as early or late biopsy-proven acute rejection and also allograft or patient survival rate across those groups. Results: Out of total 4,757 kidney transplant recipients, 348 (7.5%) cases were re-KT. The proportion of DDKT and sensitized patients was significantly higher in re-KT group compared to first KT group (DDKT; 53.4% versus 37.4%; P<0.05, sensitized patients; 21.6% versus 3.7%, P<0.05). Especially in LDKT, the proportion of ABO incompatible KT was higher in re-KT group than first KT group as well (18.5 % versus 12.5%; P<0.05). The incidence of early biopsy-proven acute rejection (BPAR) was significantly higher in re-KT group than first KT group in DDKT (19.4% versus 11.3%; P<0.05), but not in LDKT (7.4% versus 9.0%; P>.05). Incidence of late BPAR was not significantly different between re-KT and first KT groups both in DDKT (0.6% versus 2.4%; P>.05) and LDKT (1.6% versus 2.6%; P>.05). In multivariate analysis, re-KT was an independent risk factor for development of early BPAR in DDKT (odd ratio, 1.724; 95% confidence interval, 1.10 to 2.67; P<.05). However, allograft and patient survival rate were not significantly different between re-KT and first KT group in DDKT and LDKT (P>.05, for all). Conclusion: Our study showed that overall clinical outcomes of re-KT was comparable to those of first KT irrespective of donor type.
원문(PDF)	PDF 원문보기

간행물 검색

대한신장학회 회원관리 규정