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논문분류	춘계학술대회 초록집
제목	Tonsillar and fecal microbiome in IgA nephropathy
저자	Ji in PARK1, Tae yoon KIM2, Hyunjeong BAEK1, Hae hyuk JUNG1, Hyun-jeong CHO3, Hajeong LEE3, Dong ki KIM3, Seung hee YANG3, Bumjo OH4, Je hee LEE5, Jongsik CHUN5, Bong-soo KIM2, Jung pyo LEE6, *Yon su KIM3
출판정보	2017; 2017(1):
키워드	IgA nephropathy, microbiome
초록	Objectives : Mucosal immune system plays a role in pathogenesis of Immunoglobulin A nephropathy (IgAN); however, little has been known about the relationship between IgAN and the microbiome reside in tonsil and intestine. Methods : We prospectively enrolled 30 biopsy-proven IgAN patients at 3 centers and collected tonsil swabs and fecal specimens at the time of renal biopsy. Tonsil swabs and feces from different groups of thirty healthy volunteers were used as control. The composition of microbiota was analyzed using extracted metagenomic DNA from the feces and tonsil swabs by Illumina MiSeq system. Results : The fecal microbiota of both IgAN and control group were dominated by two bacterial phyla, Firmicutes and Bacteroidetes. Compared to control group, fecal microbiota of IgAN patients showed significantly lower OTUs and Shannon diversity index. The relative abundances of Firmicutes were higher, whereas those of Bacteroidetes were lower in IgAN patients than healthy subjects. The microbiota of tonsil swabs were also analyzed. Bacterial diversity was higher in IgAN patients than control group. The proportions of Firmicutes and Bacteroidetes were higher, whereas those of Proteobacteria were lower in IgAN patients than control group. When we matched age between IgAN and control groups, twelve patients and 12 healthy persons were selected, and the relative abundance of Bacteroidetes were still significantly higher in IgAN patients. Conclusions : The fecal and tonsillar microbiota of IgAN patients differed from those of control group. Such differences might be related with pathogenesis of IgAN.
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