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논문분류	춘계학술대회 초록집
제목	Asymptomatic hyperuricemia is independently associated with coronary artery calcification in the absence of overt coronary artery disease: A single center cross-sectional study
저자	Kwon soo JUNG, Donghwan OH, Seok-hyung KIM, Ah ran CHOI, Hoon young CHOI, Hyeong cheon PARK, *Hyunwook KIM
출판정보	2017; 2017(1):
키워드	coronary artery calcification; uric acid; multi-detector computed tomography
초록	Objectives : Recently, the pathogenic role of uric acid (UA) in both systemic metabolic and atherosclerotic diseases has been investigated. We sought to determine the independent correlation between serum UA levels and coronary artery calcification, as a marker of subclinical atherosclerosis Methods : Total of 4188 individuals without prior coronary artery disease or urate-deposition disease were included. All of the participants underwent multi-detector computed tomography (MDCT) for the evaluation of coronary artery calcification (CAC) during their health check-ups Results : The subjects were divided into thre groups according to CAC scores (group 1: 0; group 2: 1-299; group 3: ≥300). After controlling for other confounders, serum UA levels were found to be positively associated with increasing CAC scores (P= 0.001). Adjusted mean serum UA levels in each CAC group were estimated to be 5.2±0.1 mg/dl, 5.3±0.1 mg/dl, and 5.6±0.2 mg/dl from groups 1, 2 and 3, respectively. Subsequent subgroup analyses revealed that this positive association was only significant in participants who were male, relatively older, less overweight, and did not have diabetes mellitus (DM), hypertension, smoking history, or renal dysfunction Conclusions : In conclusion, serum uric acid levels were independently associated with CAC score severity and this finding is particularly relevant to the subjects who were male, relatively older, less overweight (body mass index <25 kg/m2), and without a history of DM, hypertension, smoking, or renal dysfunction
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