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논문분류	춘계학술대회 초록집
제목	Urine TIMP-2 and IGFBP7 can predict adverse renal outcome in established acute
저자	Jihyun YANG , Sung yoon LIM, Woori CHO, Yoon kyung CHOI, Tae yeon HWANG, Myung-gyu KIM, *Sang-kyung JO, Won-yong CHO
출판정보	2017; 2017(1):
키워드	AKI, biomarker, Critical care
초록	Objectives : Several recent studies have shown that insulin-like growth factorbinding protein 7 (IGFBP7) and tissue inhibitor of metalloproteinase-2 (TIMP-2) are promising biomarkers for the early detection of acute kidney injury (AKI). However, the role of IGFBP7 and TIMP-2 in predicting adverse clinical outcomes has not been well addressed. The purpose of this study was to evaluate the usefulness of urine IGFBP7 and TIMP-2 as outcome predictors in patients with AKI. Methods : This was a prospective cohort study of established AKI patients. Urinary biomarkers, including IGFBP7, TIMP-2, and NGAL (Neutrophil gelatinase-associated lipocalin) were determined on admission and discharge from the hospital. The primary clinical outcome variables were renal replacement therapy (RRT), renal recovery, and in-hospital mortality. Results : We prospectively enrolled 124 patients with AKI. Both urine [TIMP-2]•[IGFBP7] on the 1st day and KDIGO staging on the 7th day of AKI were independently associated with greater odds of RRT requirement and renal recovery in multiple logistic regression analysis. In the analysis of the predictive performance of urinary biomarkers, [TIMP-2]•[IGFBP7] had a better performance for predicting either RRT requirement or renal recovery than did the NGAL, which are previously known to predict adverse outcomes Conclusions : This prospective observational study could suggest that initial urine [TIMP-2]•[IGFBP7] level might serve as a strong predictor for the need for renal replacement therapy and likelihood of renal recovery in AKI patients.
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