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논문분류	춘계학술대회 초록집
제목	Protective Effects of Green Tea Extract and Gemigliptin on Acute tacrolimusinduced Nephropathy in Mice
저자	Byung chul SHIN, *Hyun lee KIM, Jong hoon CHUNG
출판정보	2017; 2017(1):
키워드	Tacrolimus, gemigliptin, nitric oxide, Green tea extract
초록	Objectives : It has been reported that the proteinuria is an early predictive marker in detection of tacrolimus (TAC) nephrotoxicity. The aim of this study was to investigate the renoprotective effects of green tea extract (GTE) and dipeptidyl peptidase IV (DPP IV) inhibitor gemigliptin on TAC-induced acute nephrotoxicity in mice. Methods : The mice (n=30) were divided into 6groups (n=5/group); control group were intraperitoneally (IP) injected 0.9% saline, TAC group were IP injected TAC2 mg/kg, DPP IV inhibitor group were given inadditiongemigliptin20 mg/kg (G20) by oral gavage. TAC-GTE group were given TAC by IP injection and GTE 100 mg/kg by subcutaneous injection. TAC-GTE-G20 group were given with same dosages Results : The 24 hours urine protein amounts were significantly increased in TAC group compared to control group and significantly decreased in TACGTE- G20group compared to TAC group. The nitric oxide (NO) production by TAC was significantly suppressed by EGCG and gemigliptin in management. Renal tissue malondialdehyde level was significantly increased in TAC group compared to control group and significantly decreased in TAC-EGCG-G20 group compared than that of TAC group. The renal function and antioxidant enzyme activities were significantly suppressed in TAC group compared with control group and restored in EGCG and gemigliptin treatment group. Conclusions : GTE and gemigliptin treatment has beneficial antiproteinuric and protective effects on TAC-induced acute renal injury in mice
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