대한신장학회

논문분류	춘계학술대회 초록집
제목	The Duration of Female Reproductive Period Is Associated with Incident Chronic Kidney Disease : A Community-based Prospective Cohort Study
저자	Shinchan KANG1, Heebyung KOH1, Joohwan KIM1, Changhyun LEE1, Sangmi LEE1, Cheol ho PARK1, Jaeyeol KWON1, Jong hyun JHEE1, Seung hyeok HAN1, Tae-hyun YOO1, Shin-wook KANG1,2, *Jung tak PARK1
출판정보	2017; 2017(1):
키워드	Chronic kidney disease, Reproductive period, Estrogen, Renoprotective effect
초록	Objectives : Recent animal studies have shown renoprotective effects of estrogen. However, clinical evidence demonstrating such relationship is scarce. This study aimed to investigate whether estrogen plays a role in affecting renal function. By assuming the reproductive period duration(RPD) as a marker of cumulative lifetime estrogen exposure, the relationship between estrogen exposure amount and the risk of CKD development was analyzed in a community-based prospective cohort Methods : Data were retrieved from the Korean Genome and Epidemiology Study (KoGES). KoGES is a prospective observational cohort including general population followed up from 2001 to 2014. A total of 2203 postmenopausal subjects with normal renal function were included in the final analysis. Duration of the reproductive period was determined as the age at menopause minus the age at menarche. The subjects were divided into quartiles according to RPD. The primary endpoint of study was development of CKD, defined as a composite of estimated glomerular filtration rate(eGFR)<60 mL/min/1.73 m2 or development of proteinuria Results : The mean age and eGFR of the subjects were 59.1 ± 5.8 years and 88.7 ± 11.5 mL/min/1.73 m2, respectively. The mean RPD was 32.1±4.4 years. Although the subjects in the longest RPD group showed higher prevalence of hypertension than the other groups, baseline eGFR were comparable among the groups. During a mean duration of 118±42 months, 822 subjects developed CKD. Cox analysis revealed that the risk for development of CKD was significantly lower in the group with the longest RPD compared to the shortest RPD group [hazard ratio (HR) 0.78, 95% confidence interval (CI) 0.64- 0.95, P = 0.014]. This finding was significant even after adjustments were made for confounding factors (HR 0.76, 95% CI 0.62-0.93, P = 0.007). Conclusions : The risk for CKD development was significantly lower in the subjects with longest RPD. Estrogen exposure may be a factor affecting renal function in females
원문(PDF)	PDF 원문보기

간행물 검색

대한신장학회 회원관리 규정