대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Circulating Renalase Predicts All-Cause Mortality and Renal Outcome in Patients with Advanced Chronic Kidney Disease
저자	Seon ha BAEK1, Ran-hui CHA2, Shin wook KANG3, Cheol whee PARK4, Dae ryong CHA5, Sung gyun KIM6, Sun ae YOON7, Sejoong KIM8, Sang-youb HAN9, Jung hwan PARK10, Jae hyun CHANG11, Chun soo LIM12, Yon su KIM13, *Ki young NA8
출판정보	2017; 2017(1):
키워드	chronic kidney disease, renalase, clinical outcomes, mortality
초록	Objectives : Patients with chronic kidney disease (CKD) show markedly increased rates of end-stage renal disease, major adverse cardiovascular and cerebrovascular events (MACCEs), and mortality. Therefore, new biomarkers are required for the early detection of such clinical outcomes in patients with CKD. We aimed to determine whether circulating renalase was associated with CKD progression, MACCEs, or all-cause mortality, using data from a prospective randomized controlled study, K-STAR (Kremezin STudy Against Renal disease progression in Korea: NCT 00860431). Methods : A retrospective analysis of the K-STAR data was performed in 383 patients with CKD (mean age: 56.4 years, men/women = 252/131). We measured circulating renalase and examined the effects of renalase on clinical outcomes. Results : The mean value of serum renalase levels was 75.8 ± 34.8 μg/mL. In multivariable analysis, lower hemoglobin, higher serum creatinine, and diabetes mellitus were significantly associated with a higher renalase level. During a mean follow-up period of 56 months, 25 deaths and 61 MACCEs occurred. Among 322 patients, 137 adverse renal outcomes occurred during a mean follow-up period of 27.8 months. Each 10-μg/mL increase in serum renalase was significantly associated with all-cause mortality and adverse renal outcome (hazard ratio [HR] = 1.112, P = 0.049; HR = 1.052, P = 0.045). However, serum renalase level was not associated with MACCEs in patients with CKD. Conclusions : Our results indicated that circulating renalase might be a predictor of mortality or adverse renal outcome in patients with CKD.
원문(PDF)	PDF 원문보기

목록

위로가기