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논문분류	춘계학술대회 초록집
제목	Differentiation of Dysmorphic RBC by Automated Urine Analyzer UF-1000i System
저자	Seyoung BAHK1, *Young ok KIM1, Sun ae YOON1, Young soo KIM1, Hyunjung KIM2, Hae kyung LEE2
출판정보	2017; 2017(1):
키워드	Hematuria ; Dysmorphic RBC ; Small RBC fraction
초록	Objectives : •The recently developed UF-1000i urine particle analyzer is a fully automated urine analyzer that incorporates flow cytometry as well as impedance detection. It claims to be specific for detection small RBC & large RBC proportion of total RBC. •Thus UF-1000i small RBC fractions may be useful in finding dysmorphism of RBC in hematuria patients thus it may give early information to find GN. •The aim of this study was to evaluate diagnostic ability & clinical significance of UF-1000i small RBC fraction in hematuria patients. Methods : [Phase Contrast Microscopy (PCM)] •Specimens were centrifuged & Sediment was resuspended in supernatant. 1 drop of sediment was then examined by PCM. •Dysmorphic RBC was defined as variation in size and shape. [UF-1000i] •Cells, bacteria, & casts are measured by electrical impedance for volume, forward light scatter for size & by fluorescent dye for nuclear & cytoplasmic characteristics. The results are displayed in scattergrams on a screen. Results : •Diagnosis & Distribution of 109 consecutive patients (male 59, female 50) with hematuria -A. Glomerulonephritis (GN) n=15 IgAN 7, MGN 2, MPGN 2, FSGS 2, Overt proteinuria 2 -B. Chronic renal disease (CRD) n=58 CKD 31, DM nephropathy 15, Isolated proteinuria 10, HSP 1, AKI 1 -C.Other renal diseases (NGN) n=36 Urolithiases 5, Infection 12, Unspecified hematuria 15, Kidney laceration 4 Conclusions : •UF1000i small RBC (%) & dysmorphic RBC(%) by PCM showed significantly different fractions between GN, CRD & NGN groups. •UF1000i small RBC (%) revealed highest levels in GN group. •UF1000i transforms labor intensive microscopic urinalysis to easy to use automated platform. •Of 42 cases which were positive in dysmorphic RBC by PCM, 40 patients showed positive UF-1000i small RBC results (95.2%). This means that UF- 1000i small RBC (%) have lower possibility of missing dysmorphic RBC. •UF-1000i small RBC (%) may help to screen dysmorphic RBC to detect GN.
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