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논문분류	춘계학술대회 초록집
제목	Genetic variants of IL-1R1 and IL-1R2 genes and IgA nephropathy risk in the Han Chinese population
저자	*Jiali WEI1, Dan NIU2, Maowei XIE1, Daofa ZHANG1, Yin ZHANG1, Xiaohong YANG1, Yan SU1, Yanni WANG1, Hui HAN1, Wenning LI1
출판정보	2017; 2017(1):
키워드	IgA nephropathy ;Genetic variants; Interleukin 1 Receptor Type I ;Interleukin 1 Receptor Type 2
초록	Objectives : IgA nephropathy (IgAN), as the most common primary glomerulonephritis in the world, is the major cause of end-stage renal disease(ESRD) in Asia and its pathogenesis is influenced by both genetic and environmental factors. Single nucleotide polymorphisms (SNPs) in IL1R1 and IL-1R2 may be associated with susceptibility to IgAN. In this study, we study the association between genetic variants of IL-1R1 and IL-1R2 and IgA nephropathy risk in the Chinese Han population. Methods : A case-control study was conducted including 426 nephropathy patients and 463 healthy controls. Chi-squared tests and genetic model were used to evaluate associations. Results : In the allelic model analysis, the rs10490571 and rs3917225 were associated with a 1.40-fold (95%CI: 1.10-1.78; P = 0.006),and 1.31-fold (95%CI:1.08-1.59; P= 0.06) increased risk of IgA nephropathy, respectively. In the genetic model analysis, the rs10490571 in IL1R1 was associated with increase 1.46-fold risk of IgAN in the dominant model and increase 1.36-fold risk in the Log-additive model, respectively. In addition, the rs12712127 in IL1R1 and rs3917225 in IL1R2 were associated with an increased risk. However, the rs3218977 in IL1R2 was associated with decrease 0.71-fold risk of IgAN in the dominant model and 0.71-fold risk in the over-dominant model, respectively. Conclusions : These findings suggest that IL-1R1 and IL-1R2 polymorphisms may contribute to the development of IgAN.
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