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논문분류	춘계학술대회 초록집
제목	Ticagrelor-induced acute kidney injury can increase serum concentration of statin, and lead to concurrence of rhabdomyolysis
저자	Inseong PARK1, *Dongwon LEE2, Soobong LEE2, Ilyoung KIM2, Eunyoung SEONG1, Sangheon SONG1, Harin RHEE1, Ihmsoo KWAK1, Minjeong KIM2, Joohui KIM2
출판정보	2017; 2017(1):
키워드	ticagrelor, acute kidney injury, rosuvastatin, rhabdomyolysis
초록	Case Study : Ticagrelor is an oral, reversible, direct-acting inhibitor of the adenosine diphosphate receptor P2Y12. Recently ticagreloris substituted for clopidogrel owing to its more rapid onset and more pronounced platelet inhibition. However, ticagrelor might cause more deterioration of renal function compared to clopidogrel, especially in the elderly patients over 75 years of age, with pre-existent renal dysfunction, and with angiotensin converting enzyme inhibitors or angiotensin II receptor blockers. An 80-year-old woman was presented with oliguria and generalized myalgia. She had been taking ticagrelor and rosuvastatin due to unstable angina. Laboratory work-up showed increased blood urea nitrogen, serum creatinine, serum cystatin C and urine NGAL, and also revealed increased serum creatine kinase, lactate dehydrogenase, and urine myoglobin, suggesting concurrence of rhabdomyolysis. Ticagrelor-induced acute kidney injury led to a rise in serum concentration of rosuvastatin, which eventually resulted in rhabdomyolysis. To our knowledge, this is the second case of ticagrelor-induced acute kidney injury causing rosuvastatin-induced rhabdomyolysis. Therefore we provide a caution that renal function deterioration and interaction with statin should be considered when prescribing ticagrelor, especially in the elderly patients.
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