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논문분류	춘계학술대회 초록집
제목	Association between Chronic Kidney Disease and Muscle Strength in Korean Population
저자	A young KIM, Jong won PARK, Seok hui KANG, Kyu hyang CHO, Joon hyuk SEO, *Jun young DO
출판정보	2017; 2017(1):
키워드	chronic kidney disease, handgrip strength, weakness
초록	Objectives : The objective of the present study was to evaluate the clinical association between chronic kidney disease (CKD) and muscle strength in Korean population. Methods : We recruited 4542 patients who were available for data regarding estimated glomerular filtration rate (eGFR) and handgrip strength and 18 years and older. CKD was defined as estimated glomerular filtration rate < 60 mL/min/1.73 m2. Muscle weakness was measured using handgrip strength and defined as <22.4kg in men and <14.3kg in women. Results : The number of participants with and without CKD was 176 and 4366, respectively. The proportion of muscle weakness was higher in patients with CKD than in those without CKD (1.1% for patients without CKD and 4.0% in patients with CKD; P < 0.001). The eGFR values were positively correlated with the handgrip strength (r = 0.235 in men and r = 0.169 in women; P < 0.001). Univariate and multivariate linear regression analyses showed that the presence of CKD was inversely associated with handgrip strength, with multivariate analyses yielding a standardized β ± standard error of the presence of CKD of –0.036 ± 0.469 (P < 0.001). Handgrip strength in patients with and without CKD was 32.8 ± 10.2 and 29.6 ± 9.0 kg, respectively (P < 0.001). Multivariate analyses yielded similar results. Conclusions : Our study showed that the CKD may be associated with a higher prevalence of muscle weakness and lower handgrip strength in the Korean population.
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