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논문분류	춘계학술대회 초록집
제목	SERUM ZINC LEVEL AS A CHRONIC INFLAMMATION MARKER IN PATIENTS WITH CHRONIC KIDNEY DISEASE
저자	Minyoung KIM1, Sungjin CHUNG1, Seok joon SHIN2, Yoon sik CHANG1, *Eun sil KOH1
출판정보	2017; 2017(1):
키워드	Zinc, Proteinuria, CKD, Inflammation
초록	Objectives : Zinc (Zn) is an essential trace element regarding cellular metabolism, tissue repair and inflammation. Serum zinc levels have been shown to decrease in ESRD patients, however, the corresponding serum zinc levels at the different pre-dialysis CKD stages, are not known. The purpose of this study was to analyze the association between serum zinc level and inflammation markers in patients with mild to moderate CKD patients. Methods : All clinical and laboratory data including measurement of serum zinc were obtained from 328 pre-dialysis CKD patients. Amount of proteinuria was measured by the total quantity of protein in a 24 hour-urine collection. Serum zinc concentration was evaluated by inductively coupled plasma mass spectrometer (ICP/MS). Results : The median value of estimated glomerular filtration rate (eGFR) and the amount of proteinuria were 34.89 ml/min/1.73m² (IQR: 12.52-84.54) and 600 mg/day (IQR: 170-2010), respectively. The median value of serum zinc level among all individuals was 68.30 ug/dL (IQR: 56.83-77.43). Serum Zn level was significantly correlated with eGFR (r=0.134; p =0.015) and the amount of proteinuria (r=0.241; p <0.001). Additionally, it was correlated with age (r=- 0.205; p <0.001), hs-CRP (r=-0.226; p <0.001), serum ferritin (r=-0.0135; p = 0.016), and serum albumin (r=0.389; p <0.001). However, serum zinc level was not different according to gender, BMI and hypertension. In multiple linear regression analysis, serum zinc level was associated negatively with inflammation markers such as serum ferritin and hs-CRP, even after controlled age, eGFR and the amount of proteinuria. Conclusions : The current results suggest that serum zinc might have some role in CKD patients in the aspect of inflammation, independently of renal loss.
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