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논문분류	춘계학술대회 초록집
제목	An Open-label, Single-arm Study Assessing Efficacy of Sirolimus Based Immunosuppression in the Renal Transplant Patient with Fibroadenoma
저자	Min ji KIM1, Byeong woo KIM2, Tae hee KIM1, Sun woo KANG 1, *Yeong hoon KIM1
출판정보	2017; 2017(1):
키워드	CNI, fibroadenoma
초록	Case Study : The incidence of fibroadenoma in the general population is 7% to 13%. With regard to the kidney transplant (KT) recipient, the increased incidence of benign breast disease in female KT patients receiving cyclosporine was reported. The mechanism of development of fibroadenomas in patients under Cyclosporine A (CsA) treatment is suggested to be multifactorial. Nowadays, there is an effort to convert from cyclosporine or tacrolimus to sirolimus to prevent from calcineurine inhibitor (CNI) toxicity. However there was no data on the effect of switch from CsA or tacrolimus to sirolimus on the progression of fibroadenomas. So we needed to get the information concerning the effect of sirolimus based immunosuppression on the fibroadenoma. The aim of this study is to assess the reversibility of breast fibroadenomas following conversion from CsA or tacrolimus to sirolimus among a small cohort of female KT recipients. Screening of 128 female KT patients at Busan Paik hospital revealed 15 breast fibroadenoma patients of more than BI-RADS category 3. 7 patients were taking tacrolimus and 8 patients were taking CsA after KT. We tested renal function, hormonal levels, category and size of fibroadenomas for 12 months after switching to sirolimus, but no statistically significant difference was found. Changing CNI to sirolumus does not change the size or category of fibroadenoma for 12 months. It seems that larger and longer studies are needed.
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