대한신장학회

논문분류	춘계학술대회 초록집
제목	Bariatric surgery reduces elevated urinary mitochondrial DNA copy number in obese patients
저자	Haekyung Lee1, Songhee Oh1, Wonmi Yang2, Jin Seok Jeon1, Hyunjin Noh1, Dong Cheol Han1, Yongjin Kim3, Soon Hyo Kwon1
출판정보	2018; 2018(1):
키워드	obesity \| mitochondrial DNA \| bariatric surgery
초록	Objectives: Obesity is an independent risk factor for chronic kidney disease (CKD). However, the mechanisms responsible for renal injury have not been totally elucidated. Mitochondrial damage is considered to have implications for renal injury, and urinary mitochondrial DNA (mtDNA) is a marker of mitochondrial damage. We hypothesized that urinary mtDNA copy number in non-diabetic obese patients would be higher than in healthy volunteers, and bariatric surgery could reverse elevated urinary mtDNA copy number. Methods: We prospectively recruited age-sex matched healthy controls and non-diabetic obese patients who were going to undergo bariatric surgery (n = 22 each; male=8, female=14) at a single center in Korea. We quantified the urinary absolute copy number of the mitochondrial nicotinamide adenine dinucleotide dehydrogenase subunit-1 (mtND-1) gene in healthy volunteers by quantitative polymerase chain reaction. In obese patients, mtND-1 copy number was measured before bariatric surgery and six months after bariatric surgery. Results: Age (35.2 ± 9.6 years vs 32.2 ± 10.0 years, P=0.213) and eGFR (108.1 ± 11.7 mL/min vs 109.7 ± 24.0 mL/min, P=0.181) in both groups were not significantly different. 24 hour urinary albumin was higher in the obese group (2.7 ± 3.0 mg/day vs 52.9± 163.6 mg/day, P<0.001). In the obese group, BMI decreased from 41.0 ± 5.7 to 36.0 ± 7.2 (P=0.002) six months after bariatric surgery. Urinary mtND-1 copy number in the obese group was higher in healthy controls (Figure 1, P=0.001). In obese patients with high urinary mtND-1 copy number, bariatric surgery reduced urinary mtND-1 copy number (P=0.006). Conclusions: Obesity is associated with elevated urinary mtND-1 copy number. Bariatric surgery reduces urinary mtDNA in obese patients with especially high mtDNA copy number. This suggests bariatric surgery would improve mitochondrial damage in kidney cells. Figure 1. Urinary mitochondrial nicotinamide adenine dinucleotide dehydrogenase subunit-1 (mtND-1) copy number before bariatric surgery
원문(PDF)	PDF 원문보기

간행물 검색

대한신장학회 회원관리 규정