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논문분류	춘계학술대회 초록집
제목	The potential role of IL-33/ST2 in renal allograft rejection
저자	Mi Yeon Yu1, Hajeong Lee1, Sunhwa Lee1, Yong Chul Kim1, Seung Seok Han1, Jung Pyo Lee2, Dong Ki Kim1, Yon Su Kim1, Seung hee Yang3
출판정보	2018; 2018(1):
키워드	Il-33 \| ST2 \| rejection \| kidney \| transplantation
초록	Objectives: Interleukin (IL)-33 and its receptor, growth stimulation gene-2 (ST2) are increased in allograft rejection. Recent studies showed that upregulation of IL-33 has protection effect against chronic allograft rejection. We hypothesized that IL-33 and ST2 expression differently express according to rejection type, acute antibody mediated rejection (AAMR), acute cellular mediated rejection (ACMR), and chronic antibody mediated rejection (CAMR). Methods: Kidney biopsy tissue were obtained from healthy controls (n=4) and kidney transplanted recipients with ABMR (n=10), ACMR (n=10), and CAMR (n=10). We evaluated the tissue expression of IL-33 and ST2 in allograft biopsies from 4 groups by quantitative immunostaining. Results: The expressions of ST2 were significantly increased in AAMR (p=0.014), ACMR (p=0.028), and CAMR (p=0.036), compared to healthy controls. On the contrary, IL-33 expressions attenuated in kidney tissue with AAMR (p=0.028) and CAMR (p=0.014). IL-33 increased in ACMR group but did not show statistical significance (p=0.580). Interestingly, IL-33 and ST2 had a positive correlation in AAMR (r=0.692, p<0.001) and ACMR (r=0.661, p<0.001), and a negative correlation in CAMR (r=-0.459, P=0.011). IL33 and ST2 levels increased after transient hypoxia via hypoxia-inducible factor (HIF)-1α in primary cultured human renal tubular cells. Conclusions: The up-expression of ST2 can be a stable hallmark of acute and chronic rejection in kidney recipient. IL-33 expression in the allograft tissue with rejection may be increased during early phases of rejection, as an alarm marker. Furthermore, we need to evaluate the role of the IL-33/ST2 axis in allograft rejection.
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