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논문분류	춘계학술대회 초록집
제목	FORMULATION AND EVALUATION OF EMBELIN LOADED PECTIN NANOPARTICLES FOR THE TREATMENT OF DIABETES
저자	SOURABH JAIN1, SAURABH BHARGAV2
출판정보	2018; 2018(1):
키워드	embelin \| diabetes \| nanoparticle \| pectin
초록	Objectives: Embelin exhibited insulin sensitizing effect through adipose tissue specific partial agonist of PPARγ and activated glucose transport through translocation and activation of GLUT4 mediated by insulin dependent PI3k/p-Akt pathway in epidermal adipose tissue. It also protected β-cells by scavenging free radicals and alleviated dyslipidemia in insulin resistant animal model. So in present study we developed embelin loaded controlled release nanoparticles using pectin. Methods: The Nanoparticles were produced via the ionotropic gelation method using the biocompatible natural polymers pectin. The polymer concentration was optimized using the 32factorial method to acquire minimum particle size. The optimum formula was further evaluated like zeta potential, particle morphology, profile spectra of FT-IR and in vitro release study. Results: Obtained optimum formula consist of 0.8% pectin with the mean entrapment efficiency of 7.59% ± 3.21, particle size of 207.2 nm ± 12.7 polydispersity index of 0.512 ± 0.021, zeta potential 40.20 mV ± 13.61, particle round and dark, ionic gelation was confirmed by FT-IR and the release profile following the kinetics Korsmeyer-Peppas models with Fickian diffusion. Conclusions: Based on the findings of the present study, it is expected that this novel formulation be a superior therapeutic alternative to the currently available embelin delivery systems.
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