대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Acute and Chronic Renal Tubular Response to SGLT2 Inhibitors in Diabetic Mice
저자	Yu-Wei Fang
출판정보	2018; 2018(1):
키워드	Sodium-glucose cotransporter \| Sodium-chloride cotransporter
초록	Objectives: Inhibition of sodium-glucose cotransporter 2 (SGLT2) in proximal renal tubules may induce glucosuria and sodium excretion to lower serum glucose in patients with type 2 diabetes mellitus.The design of this study was to explore changes in electrolyte and associated transporters. Methods: C57BLKsJ-db/db mice were used as spontaneous type 2 diabetic animal model. Dapagliflozin, a SGLT2 inhibitor, was fed with 1 mg/kg. Serum and urine were collected after 6-hours and 24-hours and kidneys were extracted for quantification of protein amount by Western blotting. Results: Fraction excretion of sodium, potassium, phosphate, calcium and magnesium were all decreased after 6 hours and increased after 24 hours.In proximal renal tubules, the insignificant changes of sodium-hydrogen exchangers 3, type 2a and 2c sodium-phosphate cotransporters were noted.The protein expression of sodium-chloride cotransporters in distal tubules and sodium-potassium-2 chloride cotransporters in thick ascending limbs were enhanced at 6 hour but decrease to baseline at 24 hour. The epithelial sodium channels increased at both 6 and 24-hour sampling. Conclusions: Inhibition of SGLT2 may alter renal tubular sodium handling and the expression of Na-dependent cotransporters. The underlying mechanism needs further exploration and investigation. Table 1 Urine and serum electrolyte change
원문(PDF)	PDF 원문보기

목록

위로가기