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논문분류	춘계학술대회 초록집
제목	KIdney diseases in elderly: renal biopsy data from one single chinese center over 30 years
저자	Chen Pu, Liu Shuwen, Zhang Xueguang, Yin Zhong, Wu Jie, Xie Yuansheng, Cai Guangyan, Chen Xiangmei
출판정보	2018; 2018(1):
키워드	elderly \| renal biopsy \| membranous nephropathy \| minimal change disease \| pathological diagnosis
초록	Objectives: The aim of the study was to explore the changes of spectrum of biopsy-proven kidney disease in the elderly Chinese patients during the past three decades. Methods: We retrospectively analyzed renal biopsy data of the elderly patients (≥60 years) from July 1987 to June 2017. Pathological diagnosis was classified according to the Revised Protocol of WHO (1995). Study period was divided at an interval of 10 years(Dec 1987-Nov 1997 vs.Dec 1997-Nov 2007 vs. July 2007-June 2017). Results: During the three decades, there were 1,567 elderly patients diagnosed by percutaneous renal biopsy, accounting for 9.0% of the total cases. The ratio of male to female was 1.56:1, with an age of 66.01±5.17 (range 60~88) years. The prevalence of pathological types was as follows: primary glomerulonephritis (PGN, 71.2%), secondary glomerulonephritis (SGN, 22.0%), tubular-interstitial nephropathy (5.7%) and other types. The most common renal disease was idiopathic membranous nephropathy (iMN, 36.2%), followed by IgA nephropathy (IgAN, 13.1%), Diabetic nephropathy (DN, 7.4%) and minimal change disease (MCD, 6.3%). Among PGN, the most common disease was iMN (50.9%), IgAN (18.5%) and MCD (8.8%). DN (33.6%) was the leading SGN, followed by ANCA-associated vasculitis (14.8%) and amyloidosis (14.2%). The spectrum of biopsy-proven kidney disease in the elderly patients varied during the past 30 years (P=0.000). The prevalence of iMN has exploded during the past 10 years, nearly double that of previous 20 years (P1-23.2% vs. P2-22.8% vs. P3-40.7%, P=0.000), and that of MCD almost doubled every 10 years (P1-1.8% vs. P2-3.8% vs. P3-7.2%, P=0.032). However, the prevalence of MsPGN (21.4% vs. 9.5% vs.3.3%, P =0.000) dropped significantly. The prevalence of IgAN and DN remained stable. Conclusions: In elderly Chinese patients, the most common kidney disease was iMN in PGN and DN in SGN. The prevalence of iMN and MCD has exploded during the past 10 years.
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