대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Synergic effects of epigallocatechin gallate and dipeptidyl peptidase IV inhibitor on tacrolimus-induced nephrotoxicity in mice
저자	Byung Chul Shin, Hyun Lee Kim, Jong Hoon Chung
출판정보	2018; 2018(1):
키워드	Tacrolimus \| dipeptidyl peptidase IV inhibit \| Epigallocatechin gallate \| Synergic
초록	Objectives: It has been reported that the proteinuria is an early predictive marker in detection of tacrolimus (TAC) nephrotoxicity. The aim of this study was to investigate the renoprotective effects of eipgallocatechin gallate (EGCG) and dipeptidyl peptidase IV (DPP IV) inhibitor gemigliptin on TAC-induced acute nephrotoxicity in mice. Methods: : The mice (n=20) were divided into 5 groups (n=5/group); control group were intraperitoneally (IP) injected 0.9% saline, TAC group were IP injected TAC 2 mg/kg, DPP IV inhibitor group were given in addition gemigliptin 20 mg/kg (G20) by oral gavage. TAC-EGCG group were given TAC by IP injection and EGCG 100 mg/kg by subcutaneous injection. TAC-EGCG-G20 group were given with same dosages. Results: The 24 hours urine protein amounts were significantly increased in TAC group (46.1 ± 10.9 mg/day) compared to control group (11.3 ± 4.4 mg/day) and significantly decreased in TAC-EGCG-G20 group (13.1 ± 5.9 mg/day, P < 0.01) compared to TAC group. The nitric oxide production by TAC was significantly suppressed by EGCG and gemiglipin management. Renal tissue malondialdehyde level was significantly increased in TAC group compared to control group and significantly decreased in TAC-EGCG-G20 group compared than that of TAC group. The renal function and antioxidant enzyme activities were significantly suppressed in TAC group compared with control group and restored in EGCG and gemiglipin treatment group. Conclusions: : EGCG and gemigliptin treatment has synergic effects with antiproteinuric and renoprotective impacts on TAC-induced acute renal injury in mice.
원문(PDF)	PDF 원문보기

목록

위로가기