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논문분류	춘계학술대회 초록집
제목	CD137-CD137L interactions regulate B-cell autoimmunity during alloimmune responses
저자	Jong Soo Lee, Kyung Sun Park, Jong-ha Park, Hyunchul Chung
출판정보	2018; 2018(1):
키워드	CD137L signaliing \| immune regulation \| transplantation \| B-cell
초록	Objectives: CD137L/CD137 costimulatory pathway seems to participate in immune regulation. In this study we address the immune rgeulatory role of CD137L signaling on alloimmune challenge. Methods: We usded mice bone marrow transplantion model. Transfer of H2-Abbm12 splenocyte to CD57BL/6 mice breaks B-cell autoimmunity which results in chronic graft-versus-host disease (GVHD) with a SLE-like phenotype. Results: In this chronic GVHD model, CD137-/- recipients were shown to be severely impaired in autoantibody production but instead had an acute type of GVHD, indicating that Th1 responses were activated in CD137-/- mice. Analysis of CD137-/- spleens demonstrated that there was an increase in IL-12-producing CD8α+ DCs, which was caused by the absence of CD137L signaling in pre-DCs. Accordingly, IFN-γ –producing donor Th1 cells were preferentially differentiated in CD137-/- spleens, providing an explanation for why chronic GVHD was converted toward acute GVHD in CD137-/- recipients. Interestingly, differentiation of follicular helper T cells was severely impaired in CD137-/- spleens and so was that of germinal center B cells and plasma cells. Conclusions: Taken together, our results suggest that CD137-CD137L interactions regulate many aspects of immune cell differentiation during alloimmune responses.
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