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논문분류	춘계학술대회 초록집
제목	Change of gut microbiome after kidney transplantation: Korean prospective study
저자	Hyunjeong Cho1, Ji In Park2, Dong Ki Kim3, Seung Hee Yang3, Jung Pyo Lee4, Yon Su Kim3, Hajeong Lee3
출판정보	2018; 2018(1):
키워드	gut microbiome \| kidney transplantation
초록	Objectives: Gut microbiota regulates the immune response, and imbalance of intestinal microorganisms is associated with various diseases. Previous studies on gut microbiome change after kidney transplantation, a major treatment for end stage renal disease, are very rare. The purpose of this study is to analyze the changes of gut microbiome after renal transplantation and to evaluate the association between bacterial composition and posttransplantation outcome. Methods: We prospectively enrolled 36 renal transplant recipients. Three months after kidney transplantation, stool specimens from 21 recipients were collected and further analyzed. The Illumina MiSeq system was used for sequencing of the 16S rRNA V4-V5 variable region. We also analyzed the gut microbiome from posttransplant recipients who underwent bacterial infections. Results: Alpha diversity analysis showed that the Chao index increased after renal transplantation (p=0.000), while the Shannon diversity index decreased (p=0.024). Phylum gut microbiota profile showed no significant differences after renal transplantation. The genera Prevotella (p=0.005), Alistipes (p=0.22) were significantly decreased in posttransplant patients. In contrast, the genera Subdoligranulum (p=0.045), Clostridium_g24 (p=0.006) was significantly increased after operation. In patients with bacterial infections, no significant differences in the bacterial composition of phylum level were identified in comparison to the patients with no infection. Bacterial infections was associated with higher abundance of the genera Clostridium_g24 (p=0.05), Pseudoflavonifractor (p=0.05) compared with no infection. Conclusions: In this study, we found increased richness and decreased diversity of gut microbiome after kidney transplantation. Also, we showed that specific microbial changes occurred after operation. Further study should be conducted on the microbiota-targeted intervention that could improve posttransplant outcomes.
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