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논문분류 춘계학술대회 초록집
제목 Obstructive sleep apnea as a risk factor for incident end-stage renal disease: A Nationwide Population-based Cohort Study from Korea
저자 Hong Sang Choi, Jeong Ho Lee, Minah Kim, Tae Ryom Oh, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
출판정보 2019; 2019(1):
키워드 Obstructive sleep apnea | End-stage renal disease | National Health Insurance
초록 Obstructive sleep apnea (OSA) is known to be associated with metabolic dysregulation and incident cardiovascular diseases. However, its association with end-stage renal disease (ESRD) has not been clarified. This study aimed to evaluate longitudinally whether OSA is an independent risk factor for ESRD. This retrospective nationwide population-based cohort study included data on 93,051 patients with OSA and 465,255 age- and sex-matched controls without OSA obtained from the Korean National Health Insurance Service database from 2009 to 2014. A Cox proportional-hazards model with multivariable adjustment was used to evaluate the association between OSA and incident ESRD. A significantly higher incident ESRD rate (odds ratio 1.274, 95% confidence interval 1.018-1.583) was observed for patients with OSA than for matched controls. The OSA group remained predictive of higher risk of ESRD incidence in subgroups of age ≥65 years, hypertension, dyslipidemia and chronic kidney disease (CKD). OSA was an independent predictor of incident ESRD.
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