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논문분류	춘계학술대회 초록집
제목	Apolipoprotein B predicts the risk of end-stage renal disease
저자	Soie Kwon, Jung Pyo Lee, Dong Ki Kim, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Seung seok Han
출판정보	2019; 2019(1):
키워드	apolipoproteins \| cholesterol \| end-stage renal disease \| lipid subfraction
초록	Apolipoprotein B (ApoB), associated with lipid particles, is known to increase the risk of cardiovascular diseases. However, the predictive value of apolipoprotein B on the end stage renal disease as a major kidney outcome remains unresolved. The predictability of ApoB was evaluated in 9,389 subjects whose ApoB, ApoA1, and lipid subfraction were profiled at the same time. Their kidney functions were estimated and followed until the event of end-stage renal disease (ESRD). The ESRD occurred in 96 patients (1.0%) during 10 years of maximum follow-up period. When several lipid parameters including ApoB, ApoA1, and lipid subfraction score were compared, ApoB was one of the significant predictors for the ESRD risk. The 2nd and 3rd tertile groups had a higher risk of ESRD than the 1st tertile group with HRs of 1.9 (1.05–3.45) and 3.0 (1.75–5.27), respectively. In this respect, the high ratio of ApoB and ApoA1 (i.e., ApoB/ApoA1) was associated with the risk of ESRD. However, ApoA1 alone did not predict the risk of ESRD. High ApoB level is associated with the risk of ESRD, even in accompany with the adjustment of lipid subfraction results. Accordingly, monitoring of ApoB may be useful to establish a strategy for a healthier kidney.
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