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논문분류	춘계학술대회 초록집
제목	Increased delta neutrophil index is associated with in hospital renal survival and mortality in alcoholic ketoacidosis patients
저자	Jun Young Lee, Han Wul Shin, You Jin Kim, Jin Jae Jeong, Mun Hee Chai, Jae Seok Kim, Byoung Geun Han, Seung Ok Choi, Min Seob Eom, Jae Won Yang
출판정보	2019; 2019(1):
키워드	alcoholic ketoacidosis \| Prognosis \| Delta neutrophil index
초록	Alcoholic ketoacidosis (AKA) is known as a benign disease, but the related mortality reported in Korea is high. We aimed to evaluate the use of DNI and other standard laboratory parameters as predictors of prognosis in AKA One hundred eighteen males with AKA were evaluated at the Wonju Severance Christian hospital between 2009 and 2014. We performed a retrospective analysis of demographic, clinical, and laboratory parameters data. Receiver operating characteristic curves (ROC) and multivariate Cox regression were used to identify renal survival and mortality. : Survival patients had lower initial DNI levels than non-survival patients (4.8±6.4 vs 11.4±12.5, p<0.001). In multivariate adjusted Cox regression analysis, higher initial increased DNI (HR 1.044, 95% CI 1.003-1.086, p=0.035), and lower initial pH (HR 0.044, 95% CI 0.004-0.452, p=0.008) were risk factors for dialysis during hospitalization. Further, higher initial DNI level (HR 1.037; 95% CI 1.006-1.069; p=0.018), lower initial pH (HR 0.049; 95% CI 0.008-0.312; p=0.001) and lower initial glomerular filtration rate (GFR) (HR 0.981; 95% CI 0.964-0.999; p=0.033) were predictors of mortality. A DNI value of 4.5% was selected as the cut-off value for poor prognosis and Kaplan-Meier plots showed that AKA patients with an initial level DNI ≥ 4.5% had lower cumulative survival rates than AKA patients with an initial DNI < 4.5%. Increased initial serum DNI levels may help to predict renal survival and prognosis in male AKA patients and this is a cost-effective and simple method.
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