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논문분류	춘계학술대회 초록집
제목	The therapeutic efficacy of water soluble coenzyme Q10 in experimental model of tacrolimus induced diabetes mellitus.
저자	YI QUAN, Kang Luo, Sheng Cui, Sun Woo Lim, Yoo Jin Shin, Chul Woo Yang
출판정보	2019; 2019(1):
키워드	micelle formulation of CoQ10 \| oil-soluble CoQ10 \| tacrolimus \| diabetes melitus \| oxidative stress
초록	Coenzyme Q10 has a central role in the generation of cellular bioenergy and its regulation, but its use is limited due to poor absorption profiles. We have developed a natural product based micelle formulation of CoQ10 (CoQ10-M), which appears water soluble and contains CoQ10. In this study, we tested its effect in experimental model of tacrolimus (TAC)-induced diabetes mellitus (DM). Rats were daily treated with TAC (1.5mg/kg, subcutaneous), oil-soluble CoQ10 (20mg/kg, P.O., CoQ10) and water-soluble CoQ10 (20mg/kg, P.O.) under 0.01% salt diet for 4weeks. After four weeks, there is no significant difference in body weight, water intake and 24hr-urine volume between the vehicle and another group. CoQ10 micelle treatment group further ameliorate hyperglycemia. IPGTT revealed that fasting blood sugar level was increased in TAC-treated groups, but it was reduced by CoQ10-M. TAC induced increased blood sugar level was also reduced by CoQ10-M in 30min, and this increase was persisted until 120min. CoQ10-M decreased the TAC-induced AUCg increasement. However, CoQ10 has no same effect. In addition, CoQ10-M further restored TAC-induced impaired islet than CoQ10. TAC-induced oxidative stress and apoptosis were also better inhibited by CoQ10 micelle compared with CoQ10. CoQ10-M decreased TAC-induced oxidative stress. In serum 8-OHdG ELISA, TAC treatment group was significantly increased 8-OHdG expression compared with VH group. The CoQ10-M group was obviously reduced the 8-OHdG expression. Furthermore, CoQ10-M decreased the apoptosis induced by tacrolimus. The number of positive cells in TUNEL staining in CoQ10-M group is less than TAC group. At the subcellular level, in TAC treatment group, number and the average size of mitochondria was decreased. CoQ10 -M increased the number and average size of mitochondria more than CoQ10. Water-soluble CoQ10 has a better effect on TAC-induced DM compared to oil-soluble CoQ10.
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