대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Elevated Urinary Mitochondrial DNA Copy Numbers in IgA Nephropathy
저자	Byung Chul Yu, Nam-Jun Cho, Samel Park, Hyoungnae Kim, Soo Jeong Choi, Jin Seok Jeon, Hyo Wook Gil, Moo Yong Park, Soon Hyo Kwon
출판정보	2019; 2019(1):
키워드	IgA nephropathy \| urinary mitochondrial DNA \| mitochondrial injury \| biomarker
초록	Mitochondrial injury plays important roles in the pathogenesis of various kidney diseases. However, mitochondrial injury in IgA nephropathy (IgAN) has not been evaluated. Here, we examined the associations among mitochondrial injury, IgAN, existing prognostic markers, and treatment outcomes. We prospectively enrolled patients with IgAN and age-/sex-matched healthy volunteers (HVs) as controls (n = 31 each). Urinary copy numbers of the mitochondria DNA (mtDNA) genes cytochrome-c oxidase-3 (COX3) and nicotinamide adenine dinucleotide dehydrogenase subunit-1 (ND1) were measured. We also measured urinary mtDNA levels at 6 months after medical treatment in patients with IgAN (n = 19). Urinary mtDNA levels were elevated in the IgAN group compared with that in HVs (p < 0.001). Urinary mtDNA levels did not correlate with existing prognostic markers. However, urinary ND1 levels were significantly higher in the low proteinuria group than in the high proteinuria group (p = 0.027). Although urinary mtDNA levels did not change after medical treatment, changes in urinary levels of ND1 and COX3 were positively correlated with changes in proteinuria (p = 0.038 and 0.024, respectively) and inversely correlated with changes in the estimated glomerular filtration rate (p = 0.033 and 0.017, respectively) after medical treatment. Mitochondrial injury played important roles in IgAN pathogenesis and may be involved in early-stage glomerular inflammation, prior to pathological changes and increased proteinuria. The correlation between changes in urinary mtDNA and proteinuria suggest that these factors may be promising biomarkers for treatment outcomes in IgAN.
원문(PDF)	PDF 원문보기

목록

위로가기