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논문분류	춘계학술대회 초록집
제목	Subclinical Relationship Between Atheroselerosis and Cystatin C in Patients with diabets Type 2
저자	Ganga Dulal, Ganga Dulal, Shreya Dulal
출판정보	2019; 2019(1):
키워드	microsoft
초록	Cystatin C (CYSC) has been found to be an independent risk factor for cardiovascular disease. We aimed to evaluate the possible association between cysc and Subclinical Atherosclerosis in patitens with Type 2 disease (CKD) We Selected 120 patitens both sexs with DT2 and CKD Aged 63.84±9.03 (25-75) years. Control group included 84 healthy subjects the same age. The intima media thickness (IMT) was measured as the distance between the Lumen-initma interface and the media adventitia interface. GFR was estimated using the Modification of Diet in Renal Disease (MDRD) equation. Patients were divided into 4 groups by cysc Levels Tertiales patients with DT2 had significantly higher mean CIMT, and TPA compared to control group cysc levels demonstrated significant positive correlation with the mean (LMT (r=0.45, p=0.011) and TPA (r=0.37, p=0.03). In multivariate logistic analyses adjusted for cardiovascular risk factor the association between CYSC and IMT remained significant (OR=2.59, 95% CI=1.06-6.33, P=0.04) in contrast, neither serum creatinine nor estimated GFR were associated with IMT (OR=0.88, 95% CI=0.78-1.00, P=0.06, or=0.96, 95% CI= 0.89-1.04, P=0.30, respectively) A receiver operating characteristic curve analysis validate the diagnostic accuracy of CYSC for CIMT. At a 1.01 mg/l cystatin (cut-off point, the sensitivity and specificity for increased CIMT were 84% and 78% Respectively (C-Statistic 0.81, 95% CI 0.71-0.90, P<0.001) Our study demonstrated a significant association of increased CYSC levels with characteristics of carotid Atherosclerosis in patients with DT2.
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