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논문분류	춘계학술대회 초록집
제목	Angiotensin II receptor blocker (ARB) alters microRNA profile of circulating exosome in patients with diabetic nephropathy
저자	Hyo Shik Kim, Haekyung Lee, Hyougnae Kim, Jin Seok Jeon, Hyunjin Noh, Dong Cheol Han, Soon Hyo Kwon
출판정보	2019; 2019(1):
키워드	Diabetes \| RAS \| exosome \| microRNA
초록	Renin-angiotensin system (RAS) is a major target of diabetes. Angiotensin II receptor blockers (ARB) decrease the mortality and morbidity of patients with diabetes. Extracellular vesicles (EVs) contain miRNAs regulate biologic process. This study attempted to identify the exosomal miNRA profile change in patients with diabetic nephropathy after ARB treatment. We prospectively enrolled age-sex matched healthy volunteers (HV) ARB naïve 6 patients (male=4, female=2) with diabetic nephropathy. After collection baseline sample, ARB (losartan 50 mg) was added to patients. Serum exosomal micro RNAs were profiled by RNA sequencing baseline and 3 months after ARB treatment. RNA sequencing identified 156 miRNAs in exosome from HV and patients. ARB decreased the expression of 6 miRNAs in exosome from patients. Three miRNAs expression was increased after ARB treatment. Biological analysis identified the predicted involved pathways of these miRNAs (table 1). Our study demonstrates ARB affect the expression of miRNAs in circulating exosome from patients with diabetes. Therefore, miRNAs change in exosome by ARB is a novel aspect of RAS. Further study needs to identify the role of these miRNAs in diabetes.
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