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논문분류	춘계학술대회 초록집
제목	Plasma RIPK3 as a biomarker of diabetic nephropathy in type 2 diabetes
저자	Nam-Jun Cho, Sang Soo Kim, Choon Hee Chung, Jeong Suk Kang, Jong-Seok Moon, Eun Young Lee
출판정보	2019; 2019(1):
키워드	Type 2 diabetes \| Diabetic nephropathy \| RIPK3 \| Necroptosis \| Albuminuria
초록	RIPK3 acts as a critical regulator of necroptosis and play an important role in kidney injuries. We investigated the role of circulating RIPK3 as a biomarker of diabetic nephropathy. Study subjects were collected from a prospective observational cohort for diabetic nephropathy. A total of 140 type 2 diabetic patients and 19 healthy control subjects were enrolled. They were followed-up with estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR). Circulating RIPK3 concentrations were assessed by ELISA. Plasma RIPK3 levels were elevated in type 2 diabetic patients compared to non-diabetic control (P = 0.029). In type 2 diabetic patients, as albuminuria worsened, plasma RIPK3 levels were increased accordingly (P = 0.006). After adjusting confounding variables, participants with the highest tertile of plasma RIPK3 had higher annual increase of UACR in type 2 diabetic patients (β = 0.210, P = 0.012) and in normoalbuminuric subgroup (β = 0.214, P = 0.007). These participants with the highest tertile of plasma RIPK3 were associated with higher incidence of renal progression (Hazard ratio [HR]: 2.29 [1.05–4.98]) and incident chronic kidney disease (CKD) (HR: 4.08 [1.10–15.13]). Circulating RIPK3 can reflect the severity of diabetic nephropathy and predict the deterioration of albuminuria and renal function. These results highlight that circulating RIPK3 could be a novel predictor for diabetic nephropathy.
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