대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	FCRL3 and MTMR3 Gene Polymorphisms Associated with IgA Nephropathy risk in the Chinese Han population
저자	Zhang Daofa, Wei Jiali, Xie Maowei, Zhang Ying, Yang Xiaohong, Li Wenning
출판정보	2019; 2019(1):
키워드	IgA nephropathy \| FCRL3 \| MTMR3 \| Single nucleotide polymorphism
초록	Immunoglobulin A nephropathy (IgAN) is determined by a combination of multiple genetic and environmental factors, but its etiology and pathogenesis are not well understood. We aim to determine whether variations in FCRL3 and MTMR3 correlate with IgAN risk indices in Chinese Han people. Eight single nucleotide polymorphisms (SNPs) of FCRL3 and MTMR3 were genotyped, and association analysis was performed. A total of 426 patients with IgAN and 498 healthy individuals, serving as the control group, were recruited for this association study. There were significant associations between FCRL3 rs11264793 (OR = 0.78; 95% CI = 0.63-0.98; p = 0.029), rs11264794 (OR = 0.81; 95% CI = 0.67-0.98; p = 0.026) and rs7522061 (OR = 0.79; 95% CI = 0.65-0.95; p = 0.012) and decreased risk of IgAN according to allele model results. Under genetic models, FCRL3 and MTMR3 were associated with the risk of IgAN. Interestingly, FCRL3 reduced the IgAN susceptibility only in females, while MTMR3 was a risk factor for IgAN only in males. In addition, FCRL3 rs11264793 and rs7522061 had protective effects regarding to different disease grades. Moreover, the haplotypes ACC (p = 0.02) and CTC (p = 0.017) of LD block rs11264794/rs7522061/rs11264799 in the FCRL3 gene were significantly associated with a decreased risk of IgAN. We suggestthat gene polymorphisms in FCRL3 and MTMR3 may remarkably influence IgAN susceptibility in Chinese Han populations. These findings may be useful in the development of early prognostics for IgAN.
원문(PDF)	PDF 원문보기

목록

위로가기