대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	β-AMYRIN RICH FRACTION OF FICUS RACEMOSA BARK ALLEVIATES DIABETIC NEPHROPATHY IN EXPERIMENTAL RATS VIA ITS ANTIOXIDANT AND ANTI-INFLAMMATORY POTENTIAL
저자	Devendrakumar Vaishnav, Vishal Airao, Samir Rabadiya, Trupesh Pethani, Sachin Parmar, Navinchandra Sheth
출판정보	2019; 2019(1):
키워드	Anti-inflammatory \| Antioxidant \| Cytokines \| Diabetic nephropathy \| GC-MS
초록	Diabetic nephropathy (DN), characterized by renal structural and functional changes, that develops in diabetic individuals. The present study was sought to investigate the effect of β-amyrin rich fraction of Ficus racemosa (BARFFR) on modulating DN via antioxidant and anti-inflammatory potential. The known amount of F. racemosa bark powder was extracted with methanol. Methanolic extract was serially fractioned with n-Hexane, chloroform, ethyl acetate, n-butanol, and water to get BARFFR. The presence of β-amyrin was confirmed by GC-MS analysis. An experimental diabetic rat model was induced by single i.v. injection of streptozoticin (STZ) (45 mg/kg). The BARFFR was orally administrated at a dose of 20, 40, and 80 mg/kg/day. Renal function was evaluated by serum and urine chemistry. Metabolic profiles, renal enzymes and oxidative stress were estimated by biochemical tests. Cytokines were detected by ELISA. The pathological changes were assessed by histopathologic analyses. GC-MS analysis revealed the presence of β-amyrin (57.20%) in ethyl acetate fraction of methanolic extract of F. racemosa. After injection of STZ, diabetic rats exhibited renal dysfunction, as evidenced by reduced creatinine clearance, increased blood urea nitrogen and proteinuria, marked increases in lipid peroxidation, decrease in anti-oxidant enzyme and altered cytokines levels. All of these abnormalities were significantly reversed by BARFFR in dose dependent manner. BARFFR also restored the cellular anatomy of kidney compared to diabetic rats as evidenced in histopathological analyses. The data of the present study indicates that BARFFR produce dual protection of diabetic kidney through antioxidant and anti-inflammatory activities, which suggests that BARFFR is a potential adjuvant therapy for the prevention and treatment of DN.
원문(PDF)	PDF 원문보기

목록

위로가기