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논문분류	춘계학술대회 초록집
제목	Identifi cation of potential chemical risk factors for renal function among Korean women
저자	Habyeong Kang, Sunmi Kim, Gowoon Lee, Inae Lee, Jung Pyo Lee, Jeonghwan Lee, Hyunwoong Park, Gyuyeon Choi, Kyungho Choi
출판정보	2019; 2019(1):
키워드	chemical risk factor \| chronic kidney disease (CKD) \| albuminuria \| phthalates \| benzophenones
초록	Exposure to environmental pollutants (i.e., heavy metals and melamine) has been revealed to damage kidney function. Recently, endocrine disrupting chemicals (EDCs) such as phthalates and bisphenol A have been also suggested as risk factors for chronic kidney diseases (CKD). So far, however, most studies have associated a limited number of urinary chemicals with CKD. In this study, employing Korean female population aged 20-45 years (n=441), potential chemical determinants of the urinary albumin-to-creatinine ratio (ACR) were identified among multiple urinary EDCs. The creatinine-adjusted concentration of each chemical in urine was associated with ACR in a linear model adjusted for relevant covariates (single-pollutant model). Then, chemicals with a significant positive association with ACR in the single-pollutant model were included in a multi-pollutant model to evaluate their association with ACR. As a sensitivity analysis, quartile analyses were performed for the subpopulation with normal kidney function (ACR < 9.71 mg/g) to prevent potential reverse causality due to kidney dysfunction. The analyses were replicated with the specific-gravity-adjusted urinary concentrations of the compounds. In the single-pollutants model, several urinary compounds were significantly associated with ACR. However, in the multi-pollutant model, significant positive associations were observed only for monobutyl phthalate (MBP) and benzophenone-1 (BP-1), which are urinary metabolites of dibutyl phthalate and benzophenone-3, respectively. The significance of the association of these compounds remained as well among the subpopulation with healthy renal function (ACR < 9.71 mg/g) and/or with a different adjustment of urine dilution. Among the multiple urinary chemicals, MBP and BP-1 consistently and strongly associated with urinary ACR. The observation of this study warrants confirmation in other populations and experimental studies.
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