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논문분류	춘계학술대회 초록집
제목	Allergic rhinitis is closely correlated with impaired kidney function: A nationwide cross sectional study
저자	Sangmi Lee, Shinchan Kang, Seon Yeong Lee, Jee Young Lee, Young Su Joo, Hae-Ryong Yun, Jung Tak Park, Seung Hyeok Han, Shin-Wook Kang, Tae-Hyun Yoo
출판정보	2019; 2019(1):
키워드	allergic rhinitis \| impaired kidney function
초록	It is well known that the chronic inflammation is associated with renal dysfunction. Allergic rhinitis is a type of chronic inflammatory disease, however, the relationship between allergic rhinitis and chronic kidney disease has not been elucidated, yet. A total of 11,684 adults who participated in The Korean National Health and Nutrition Examination Survey VI (KNHANES VI), a nationwide cross sectional study in Korea from 2013 to 2015, were included in the analysis. We examined the association between the history of allergic rhinitis and a reduced renal function, which was defined as an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 in this cohort. We classified into the control and allergic rhinitis group according to the presence of allergic rhinitis history. There were 10,200 (87.3%) subjects without allergic rhinitis and 1,484 (12.7%) subjects with allergic rhinitis. The mean age was 50.7 ± 16.7 years and subjects who have allergic rhinitis were younger compared to that in subjects without allergic rhinitis. The subjects who have a reduced renal function were 320 (3.1%) in the control group and 65 (4.4%) in the allergic rhinitis group (P = 0.012). The subjects with allergic rhinitis had higher risk of a reduced renal function (odds ratio [OR], 1.41; 95% confidence interval [CI], 1.08-1.86) compared with the subjects without allergic rhinitis in unadjusted model, and the result was still significant after adjustment for demographic and clinical variables. Moreover, the risk for a reduced renal function in the allergic rhinitis group was steadily increased as the longer duration of allergic rhinitis (ORs, 1.15 [95% CI, 0.68-1.92]; 1.69 [95% CI, 1.09-2.64]; and 1.87 [95% CI, 1.21-2.88], in the shortest, middle, and longest tertile, respectively) compared to that in the control group after adjustment for confounding factors. We suggested that allergic rhinitis is closely associated with impaired kidney function.
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