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논문분류	춘계학술대회 초록집
제목	Plasma endocan level as a predictor of the cardiovascular risk in patients with end-stage renal disease
저자	Min Hye Kang, Yang Gyun Kim, Ju Young Moon, So-Young Lee, Shin Young Ahn, Gang Jee Ko, Hong Joo Lee, Dong Young Lee, Kyung Hwan Jeong, Sang Ho Lee
출판정보	2019; 2019(1):
키워드	Endocan \| cardiovascular \| end stage renal disease \| hemodialysis
초록	Endocan, a potential biomarker of endothelial dysfunction, has been shown to be associated with an increased cardiovascular risk. We investigated the utility of plasma endocan in predicting the cardiovascular risk of patients with end-stage renal disease (ESRD) on hemodialysis. Adult patients with ESRD undergoing hemodialysis were prospectively enrolled in K-cohort (CRIS no. KCT0003281) that is comprised of 6 tertiary hospitals of South Korea from June 2016 to May 2018. Plasma level of endocan of these patients were measured at enrollment day and their clinical characteristics were checked. Then, the development of the composite cardiovascular outcomes was monitored until December 2018. A total of 352 patients with ESRD on hemodialysis were enrolled. The composite cardiovascular outcomes were occurred in 50 patients (14%). In multiple linear regression analysis, plasma endocan level was associated with higher body mass index and pre-dialysis systolic blood pressure, lower serum albumin level, and previous history of acute coronary syndrome (ACS) and stable angina. Cox proportional-hazard analysis showed that diabetes, ACS, arrhythmia, lower HDL, and higher plasma endocan were independently associated with increased cardiovascular composite outcomes. The patients with level of endocan > 3.2 log pg/mL showed significantly higher cumulative incidence of the composite cardiovascular events (hazard ratio 4.5) (p < 0.001). Plasma endocan level is associated with multiple cardiovascular risk factors and may be a useful biomarker for macrovascular endothelial dysfunction in patients with ESRD on hemodialysis.
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