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논문분류	춘계학술대회 초록집
제목	Circulating PCSK9 level predicts risk of cardiovascular events death in hemodialysis patients
저자	Ji Yoon Kong
출판정보	2019; 2019(1):
키워드	PCSK9 \| cardiovascular event \| hemodialysis
초록	The proprotein convertase subtilisin/kexin type 9 (PCSK9) is a promising new target for prevention of cardiovascular event (CVE). However, the clinical significance of circulating PCSK9 is unclear in HD patients. A total of 353 patients were prospectively enrolled from June 2016 to May 2018 in K-cohort study groups. Serum PCSK9 level was measured at the time of study enrollment. The primary endpoint was defined as composite of CVE, and death from any cause. Baseline serum glucose level, serum albumin level, total cholesterol, and statin use was independently correlated with circulating PCSK9 in multivariate linear regression analysis. In adjusted Cox-regression analysis, PCSK9 tertile 3 was associated with 1.99-fold risks for composite event (95% confidence interval [CI], 1.08-3.66). The patients with PCSK9 tertile 3 also had an independent risk for CVE (hazard ratio [HR], 2.26; 95% CI, 1.11-4.62). This prognostic significance was prominent in patients with lower level of triglyceride, lower level of low density lipoprotein and no statin treatment. Circulating PCSK9 level independently predicts CVE and death in HD patients, and these results anticipate future studies for the effect of PCSK9 inhibition in HD patients.
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