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논문분류	춘계학술대회 초록집
제목	Malignancy in Children with Kidney Transplantation: A single-center experience
저자	Jiwon Jung, Joo Hoon Lee, Young Seo Park
출판정보	2019; 2019(1):
키워드	Children \| Kidney transplantation \| malignancy \| PTLD
초록	We aimed to investigate the incidence, manifestations, and outcomes of malignancy after pediatric kidney transplantation in Asan Medical Center. We retrospectively reviewed medical records of 143 patients aged under 18 years old who had kidney transplantation between January 1990 and January 2019 at a single center. Patients had kidney transplantation at an average age of 14.3 (interquartile range (IQR) 10.7 – 16.5) years, with mean follow up period of 10.6 (IQR 4.7 – 18.0) years. In total, 11 patients (7.7 % of kidney transplant recipients) had malignancy after kidney transplantation. Malignancy was diagnosed at an average age of 19.5 (IQR 18.6 – 21.3) years, with a mean period of 5.1 (IQR 3.0 – 10.1) years after transplantation. Eight patients (72.7 % of patients diagnosed with malignancy) were diagnosed as post-transplant lymphoproliferative disease(PTLD), and other 3 patients had papillary thyroid cancer, mucoepidermoid cancer of hard palate, and T-cell acute lymphoblastic leukemia(ALL), respectively. PTLD was diagnosed at a mean period of 3.9 (IQR 1.9 - 5.9) years after transplantation, at an average age of 19.3 (IQR 17.1 - 19.5) years. Three patients with PTLD (37.5 % of the patients diagnosed with PTLD) expired; two patients within 3 months and one patient within 1 year from diagnosis. Among 3 patients with malignancy other than PTLD, one patient with mucoepidermoid cancer showed progression despite resection and chemotherapy. Other two patients were cured without recurrence. Four patients (50.0 %, 4/8) among the survivors are currently showing normal glomerular filtration rate which did not deteriorate during the treatment of malignancy. PTLD was the most common malignancy after kidney transplantation in children, occurring at 5.6 % of patients within average of 3.9 years (IQR 1.9 - 5.9) after transplantation in our center.
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