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논문분류	춘계학술대회 초록집
제목	Role of calcitriol on Wnt 5a expression in osteoblast
저자	Kuo-Cheng Lu, Chien-Lin Lu
출판정보	2019; 2019(1):
키워드	Calcitriol \| Bone anabolism \| Wnt 5a \| Secondary hyperparathyroidism
초록	Physiologic levels of calcitriol has the direct role in promoting bone remodeling process, and enhance osteoblast function through the interaction of osteoclast-derived factors (clastokines). However, in most clinical scenario, we use therapeutic (pharmacological) doses of calcitriol. The goal of our work was to examine the therapeutic dose of calcitriol on the expression of Wnt 5a on osteoblast. To determine the source of Wnt 5a, 7F2 preosteoblast were treated with different doses of calcitriol and the Wnt 5a content evaluated by Western blot. After preosteoblast 7F2 cell stimulated with 100 ug/ml ascorbic acid, and 10 mM β-glycerol phosphate, western blot analysis showed Wnt 5a expression in osteoblast at different doses of calcitriol was significantly different at the protein level. The anablic effect of calcition when treating secondary hyperparathyroidism might came the expression of Wnt 5a from osteoblast.
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