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논문분류	춘계학술대회 초록집
제목	Glomerular hyperfiltration is associated with high risk of dementia: Nationwide population-based study
저자	Min Woo Kang, Sehoon Park, Soojin Lee, Kyungdo Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
출판정보	2019; 2019(1):
키워드	Glomerular hyperfiltration \| Dementia \| Vascular demenita \| Alzheimer's dementia
초록	Because prevention of dementia is critical before it occurs, identifying the risk factor of dementia is important. The object of this study is to identify the risk of dementia in people with glomerular hyperfiltration. Using Korean National Health Insurance Database (NHID), we retrospectively reviewed total of 2,259,502 people, excluding ESRD patients and people with dementia before taking national health screening. Study population was divided into gender and age of five-years interval group. All eGFR≥95 percentile subjects in each group which was divided into sex and age of five-years were defined as hyperfiltration group. All 50 percentile≤eGFR<65 percentile subjects in each group which was divided into sex and age of five-years were defined as reference group. The hazard ratios (HR) for all type dementia, vascular dementia and Alzheimer’s dementia were calculated based on the estimated glomerular filtration rate group after adjustment for multiple variables. The corresponding eGFR values of hyperfiltration group were ≥114 mL/min/1.73m2 in 45-49 years old male, ≥83 mL/min/1.73m2 in ≥90 years old male and ≥117 mL/min/1.73m2 in 45-49 years old female, ≥85 mL/min/1.73m2 in ≥90 years old female. The hyperfiltration group (eGFR≥95percentile) showed a higher risk of all type dementia compared with the reference group (50percentile≤eGFR<65percentile), with the following HRs: 1.07 (95% CI: 1.014–1.130). The hyperfiltration group had higher risk of vascular dementia with the following HR: 1.20 (95% CI: 1.027–1.392). The relationship between hyperfiltration and Alzheimer's dementia was not statistically significant, with the following HRs: 1.029 (95% CI: 0.967–1.096). Glomerular hyperfiltration is associated with increased risk of dementia, especially vascular dementia.
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