대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Impact of Conversion from Cyclosporine to Tacrolimus on Glucose Metabolism and Cardiovascular Risk Profiles in Long-Term Stable Kidney Transplant Recipients
저자	Jeong-Hoon Lim, Inryang Hwang, Jang-Hee Cho, Hee-Yeon Jung, Ji-Young Choi, Sun-Hee Park, Yong-Lim Kim, Chan-Duck Kim
출판정보	2019; 2019(1):
키워드	cyclosporine \| tacrolimus \| kidney transplantation \| cardiovascular risk \| glucose
초록	Compared with tacrolimus, cyclosporine increases cardiovascular risk. Furthermore, tacrolimus has a negative effect on glucose metabolism compared with cyclosporine. This study investigated the effect of the conversion from cyclosporine to tacrolimus for immunosuppressive therapy on glucose metabolism and cardiovascular risk profiles in long-term stable kidney transplant recipients (KTRs). In this prospective, open-label, single arm study, 36 KTRs were enrolled. Three were excluded. Patients were evaluated for glucose metabolism and cardiovascular risk factors at baseline, 3-, and 6-months after conversion of medication. Serial changes were analyzed by repeated measures analysis of variance. The mean duration from transplantation was 12.6 ± 4.0 years and baseline serum creatinine levels were 1.10 ± 0.23 mg/dL. After conversion, fasting plasma glucose levels increased sequentially from 101.7 ± 18.5 to 107.4 ± 21.3 mg/dL (P=0.007), and glycated hemoglobin levels increased from 5.7 ± 0.8 to 6.0 ± 1.2 % (P=0.016). Among cardiovascular risk factors, fibrinogen levels were decreased (P=0.015), but other factors including blood pressure and lipid profile were not changed (all P>0.05). There was no change in renal function, including the serum creatinine (P=0.611) and urine protein-to-creatinine ratio (P=0.092). Body mass index levels were decreased (P=0.037) and body weight showed a decreasing tendency (P=0.063). Switching of immunosuppressant to tacrolimus has an apparent negative effect on glucose metabolism and an unclear advantage on cardiovascular risk profiles for long-term stable KTRs.
원문(PDF)	PDF 원문보기

목록

위로가기