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논문분류	춘계학술대회 초록집
제목	Glaucoma incidence in kidney transplant recipients in South Korea: a long-term population-based study.
저자	Yong Chul Kim, Sehoon Park, Ji Eun Kim, Mi-yeon Yu, Seon Ha Baek, Kyungdo Han, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Hajeong Lee
출판정보	2019; 2019(1):
키워드	glaucoma \| end-stage renal disease \| kidney transplantation
초록	The risk of glaucoma is known to increase in patients with chronic kidney disease, especially end-stage renal disease (ESRD). However, little is known about the incidence and correlates of glaucoma after kidney transplantation (KT). In this study, we aimed to compare the incidence of glaucoma of KT recipients compared with ESRD patients and healthy controls (HCs) in a long-term population-based cohort. We analyzed a Nationwide Health Insurance Database of South Korea and identified patients who received KT from the year of 2007 to 2015. After exclusion of previous history of glaucoma, KT recipients were selected and matched with ESRD patients and HCs with respect to age, sex and inclusion year. KT and ESRD patients were further matched with diabetes and hypertensions. The incidence (incidence ratio, IR per 1000) of glaucoma in KT recipients was compared with ESRD patients and HCs, respectively. A total of 9,623 patients were analyzed in all three groups. Their mean age was 45.3 ± 10.7 years and 58.3% were men. When compared with HCs, the incidence of glaucoma was significantly higher in KT recipients (HCs vs KT: IR, 1.5 vs 8.3 per 1000 patient-year; adjusted HR [aHR], 2.65; 95% confidence interval [CI], 1.82-3.88), as well as in ESRD patients (HCs vs ESRD: IR, 1.5 vs 9.3; aHR, 3.10; 95% CI, 2.12-4.55). There was no difference in the risk of glaucoma between ESRD patients and KT recipients (IR, 9.3 vs 8.3; aHR, 0.86; 95% CI, 0.73-1.01). In multivariate regression, old age, male, and diabetes were associated with increased risk of glaucoma although hypertension and preemptive KT didn’t show statistical significance in KT recipients. KT recipients showed a similar risk for glaucoma with ESRD patients, and the risk was greater than HCs. Increasing age, male gender, and diabetes was a risk factor for glaucoma in KT recipients.
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