대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Association of serum uric acid level and long-term outcome in chronic kidney disease from the KoreaN Cohort Study for Outcomes in Patients with Chronic Kidney Disease (KNOW-CKD)
저자	Yunmi Kim, Hoseok Koo, Tae Hee Kim, Sun Woo Kang, Kook-Hwan Oh, Curie Ahn, Yeong Hoon Kim
출판정보	2019; 2019(1):
키워드	Chronic kidney disease \| Uric acid \| Renal outcome
초록	Hyperuricemia is an independent risk factor for microalbuminuria and decline of renal function. Though, it has not been proven whether it predicts renal outcome in chronic kidney disease patients. Among the 2,238 patients enrolled in the KoreaN cohort study for Outcomes in patients With Chronic Kidney Disease (KNOW-CKD), 1,039 patients whose serum uric acid were measured more than 3 times were included. Patients were classified into three groups according to uric acid level by trajectory analysis using K-means. We investigated baseline characteristics and outcomes of each group. Renal events were defined as either doubling of creatinine, estimated glomerular filtration rate halving, or end-stage renal disease. Composite events were defined as either death, non-fatal cardiovascular disease, or renal event. Mean uric acid level was 6.29 ± 1.28 mg/dL for group A, 8.53 ± 1.26 mg/dL for group B, and 4.91 ± 1.36 mg/dL for group C. Men accounted for 64.1%, 70.4%, and 42.4% in group A, group B, and group C, respectively. Proportion of patients with hypertension (99.0%) and diabetes mellitus (DM) (24.2%) were the greatest in group B whose uric acid was the highest. The risk of renal event was 2.01-fold higher in group B (95% CI 1.43-2.84, P < 0.001) than group A when adjusted for age, sex, hypertension and DM, and 2.16-fold higher (95% CI 1.24-3.75, P = 0.006) when additionally adjusted for other relative factors. The risk of composite event of group B was also significantly higher compared with group A after adjustment for age, sex, hypertension, and DM (HR 2.37, 95% CI 1.62-3.47), and after adjustment for additional factors (HR 2.99, 95% CI 1.60-5.68, P <0.001). High uric acid level was associated with adverse renal outcome and composite outcome in chronic kidney disease patients by trajectory analysis.
원문(PDF)	PDF 원문보기

목록

위로가기