대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	Urinary cMet can be used as a prognostic marker in immunoglobulin A nephropathy
저자	Jung Nam An, Lilin Li, Jin Hyuk Kim, Yong Chul Kim, Dong Ki Kim, Yun Kyu Oh, Chun Soo Lim, Yon Su Kim, Seung Hee Yang, Jung Pyo Lee
출판정보	2020; 2020(1):
키워드	urinary cMet \| immunoglobulin A nephropathy \| prognostic marker \| cMet agonistic antibody
초록	cMet is critical in regulating inflammation, apoptosis, and fibrosis. We investigated the correlation between urinary cMet (ucMet) levels and clinical parameters in immunoglobulin A nephropathy (IgAN). We also examined the effects of cMet agonistic antibody (cMet Ab) in an in vitro IgAN model. Patients diagnosed with IgAN (n = 179) were divided into groups 1, 2, and 3, representing undetectable, below median, and above median levels of ucMet/creatinine (Cr). Stained kidney samples were graded according to cMet intensity. Primary-cultured human mesangial cells were stimulated with recombinant tumor necrosis factor (TNF)-α and treated with cMet Ab. ucMet/Cr levels were positively correlated with proteinuria (P < 0.001). During follow-up, patients in group 3 showed a significantly lower probability of complete remission (CR) than those in groups 1 and 2. The result remained significant after adjusting for blood pressure, estimated glomerular filtration rate, and proteinuria, which influence clinical prognosis (HR 0.61, 95% CI 0.37-0.98, P = 0.042). Particularly, in patients with proteinuria ≥ 1 g/day, as ucMet/Cr levels increased, the probability of CR decreased (HR 0.24, 95% CI 0.12-0.46, P < 0.001). ucMet/Cr levels were associated with glomerular cMet expression. After TNF-α treatment, the proliferation of mesangial cells and increased interleukin-8 and intercellular adhesion molecule-1 expression were markedly reduced by cMet Ab in vitro. ucMet/Cr levels were significantly correlated with proteinuria, glomerular cMet expression, and the probability of CR. Inflammation and proliferation of mesangial cells were alleviated by cMet Ab treatment. ucMet could be clinically significant in treating IgAN.
원문(PDF)	PDF 원문보기

목록

위로가기