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논문분류	춘계학술대회 초록집
제목	Effects of Probiotic Supplementation on Reno-protective and Oxidative Stress Indices in subjects with Diabetes mellitus: A Randomized Double-Blind Clinical Trial
저자	Senthil Kumar Subramani, Rohit Sharma, Arjun Yadav, Shailendra Raghuwanshi, GBKS Prasad
출판정보	2020; 2020(1):
키워드	Probiotics \| Reno-protective \| Oxidative stress \| Type II diabetes Mellitus
초록	Kidney disease is one the secondary complications of diabetes. Probiotics are live microorganisms promoted with claims that they provide health benefits when consumed adequate amount, health benefits including antidiabetic, anti-inflammatory and antioxidant properties. This study aimed to determine the effects of probiotic supplementation on renal function and oxidative stress biomarkers in Type II Diabetes mellitus (T2DM) patients. In a randomized double-blind placebo-controlled clinical trial, 60 Subjects with aged 30–65 years were selected from CTR, Jiwaji University and assigned into two groups; Subjects in the probiotic group received a daily capsule containing Lactobacillus acidophilus, Bifidobacterium bifidium & Saccharomyces boulardii each 0.5 Bn/g and Lactobacillus plantarum, Bacillus clausii each 0.25 bn/g with 125mg FOS. BD for 12 weeks. (Placebo group only 125mg FOS in a capsule). In the baseline and at the end of the study, physical activity levels, and dietary intakes were assessed. Anthropometric parameters, blood glucouse, creatinine, urea, BUN , uric acid malondialdehyde (MDA), superoxide dismutase (SOD), reduced glutathione (GSH), and catalase (CAT) activities were measured.Statistical analysis was carried out using a paired t-test and student t- test. There was no significant difference between the two groups for demographic characteristics, anthropometric parameters at the baseline of study. The mean fasting blood glucose levels were reduced by 16.3 %.The probiotic supplementation resulted in a significant improvement in Urea by 14.7 , 13.9% BUN 14.2, 10.5% Uric acid 11.8, 8.9 % Creatinine 11 ,6% in subjects taken probiotic placebo capsules respectively. It also observed that the significant increase in GSH(p< 0.01), SOD(p< 0.01), CAT(p< 0.01) and decrease in MDA level (p< 0.01). Significant difference was observed between-group for these enzymes activities & other parameters at the end of the study. Overall, the results demonstrate that probiotics could improve renal function and oxidative stress factors among T2DM patients.
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