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논문분류	춘계학술대회 초록집
제목	Post-transplant collagen I and collagen III antibodies and antibody-mediated rejection in kidney transplantation recipients.
저자	Sehoon Park, Seung Hee Yang, Jiyeon Kim, Yong Chul Kim, Yon Su Kim, Jongwon Ha, Kyung Chul Moon, Eun Yong Song, Hajeong Lee
출판정보	2020; 2020(1):
키워드	Antibody mediated rejection \| transplantation \| Rejection \| non-HLA antibodies
초록	We explored the association of HLA and non-HLA antibodies and AMR in kidney transplantation recipients. The study included transplant recipients in one of the tertiary hospitals in Korea. We collected post-transplant sera from 72 kidney transplant recipients when biopsies revealing AMR were performed. As a control group without rejection, 82 post-transplant sera from transplant recipients without rejection and as a T-cell mediated rejection control group, 65 sera from patients with T-cell mediated rejection but without AMR were included. The titers of non-HLA antibodies were measured by the Luminex, LABScreen Autoantibody (One Lambda) and reported as mean fluorescence intensity values. We measured the titers of 41 non-HLA antibodies that are potentially associated with AMR. The baseline characteristics of the AMR group and the control groups were relatively similar, except for that the AMR cases were diagnosed in the later periods from transplantation and had a higher proportion of HLA mismatched cases and cases with positive donor-specific antibody. The titers of collagen I and collagen III antibodies were significantly higher in the AMR cases, both when compared to the no rejection group and the T-cell mediated rejection only group. The titers of collagen I and collagen III antibodies did not differ according to the presence of DSA or other diagnosis within the AMR group. Among the AMR cases, those with higher titers of collagen I or collagen III antibody had more severe degrees of peritubular capillaritis. The presence of high (> 75 percentile) collagen I antibody titer [adjusted odds ratio 8.29 (2.92-25.66)] and collagen III antibody titer [adjusted odds ratio 11.74 (3.86-40.28)] were significantly associated with the odds for AMR. Post-transplant collagen I and collagen III antibodies may be novel non-HLA antibodies that are related to AMR of kidney allograft.
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