대한신장학회

Skip Navigation: Skip to contents

KOR
ENG
전체메뉴보기

간행물 검색

현재 페이지 경로

HOME
간행물
간행물 검색

논문분류	춘계학술대회 초록집
제목	The early increase of urinary exosomal BK virus microRNA as a predictive marker for BK virus nephropathy: a prospective kidney transplantation cohort
저자	WON HEE CHO, SU WOONG JUNG, JUNG WOO SEO, KYUNG HWAN JEONG, JIN SUG KIM, CHAN DUCK KIM, BYUNG HA CHUNG, JAE BERM PARK, YEONG HOON KIM, SANG HO LEE
출판정보	2020; 2020(1):
키워드	urinary exosomal bkv-miR-B1-5p \| BK virus nephropathy \| kidney transplantation \| biomarker
초록	BK virus-encoded microRNAs are present in urinary exosomes obtained from patients with BK virus nephropathy (BKVN). Previously, urinary exosomal bkv-miR-B1-5p was found to be significantly associated with BKVN in a cross-sectional study. However, its posttransplant time-dependent changes and its predictive value for BKVN have not been investigated in a prospective study. In a prospective multicenter cohort of 422 kidney transplant recipients, urinary exosomal bkv-miR-B1-5p were examined at 0.5, 3, 6, and 12 months after kidney transplantation. All enrolled patients were reviewed to identify the patients diagnosed with BKVN histologically (definitive BKVN) and those with presumptive BKVN (plasma BK virus DNA load > 4 log10 copies/ml). The patients without biopsy-proven and presumptive BKVN were designated as No BKVN. Urinary exosomal miR was quantified using real-time PCR. The median time (interquartile range) to biopsy-proven BKVN was 3.9 (2.8-5.4) months. In patients with biopsy-proven and presumptive BKVN, urinary exosomal bkv-miR-B1-5p level and plasma BKV DNA load showed a similar time-dependent change as shown by being highest at 3 months posttransplant and thereafter decreasing. However, at 2 weeks posttransplant, the urinary exosomal bkv-miR-B1-5p level in patients with biopsy-proven BKVN was significantly higher than that of No BKVN, whereas plasma BKV DNA load was nearly undetectable in both groups. This finding indicates that an increase in urinary exosomal bkv-miR-B1-5p level is an earlier event to BKVN than BK viremia. In cox regression, urinary exosomal bkv-miR-B1-5p levels at 2 weeks and 3 months posttransplant independently predicted subsequent BKVN development. The high level of urinary exosomal bkv-miR-B1-5p during the early period of kidney transplantation may be served as a predictive marker for BKVN, enabling early intervention.
원문(PDF)	PDF 원문보기

목록

위로가기