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논문분류	춘계학술대회 초록집
제목	Anemia significantly increases Risk of Osteoporosis in Patients with Non-dialysis Chronic Kidney Disease
저자	Seonyeong Lee, Yooju Nam, Shinchan Kang, Hyung Woo Kim, Jung Tak Park, Seung Hyeok Han, Shin-Wook Kang, Kyu Hun Choi, Tae-Hyun Yoo
출판정보	2020; 2020(1):
키워드	CKD \| anemia \| bone mineral density
초록	Anemia was frequently observed in chronic renal failure patients. The risk of osteoporosis is higher in patients with chronic anemia. Chronic anemia also showed a close relationship with bone mineral density (BMD). However, few studies has been done whether anemia affects bone mineral density with CKD patient. Therefore, the aim of our study is to evaluate the relationship between anemia and BMD in a large sample of non-dialysis CKD cohort. We performed an observational study in 2,089 patients who measured hemoglobin and BMD with non-dialysis CKD enrolled in the KNOW-CKD. Anemia was defined as hemoglobin(Hb) levels of < 13.0 g/dL for males and 12.0 g/dL for females, respectively. BMD was estimated by dual energy x-ray absorptiometry system. The observed variable was decline of BMD during follow up. The mean age was 53.6 ± 12.2 years and 1,292(61.1%) patients were males. The BMD score was positively correlated with hemoglobin levels (β, 0.007; 95% CI, 0.003-0.012; P 0.002), but inversely with prevalence of anemia (β, -0.03; 95% CI, -0.042--0.008; P 0.004). In the multivariable logistic regression model, the prevalence of osteoporosis was significantly higher in the anemia group than that in the normal hemoglobin levels (odds ratio [OR], 1.67; 95% confidence interval [CI], 1.11-2.51, P=0.014). Among 881 patients except unavailable following BMD, 396 (19.7%) patients developed the decline of BMD during a median follow-up duration of 48 (interquartile range, 46-49) months. In the fully adjusted multivariable Cox models, risk of developing the decline of BMD was significantly higher in the anemia group (HR, 1.38; 95% CI, 1.02-1.87; P= 0.036) as compared to normal hemoglobin group. We found that anemia is independently and significantly correlated with an increased risk of osteoporosis with non-dialysis CKD. Our study suggests that prompt correction of anemia in CKD patients could be beneficial to preserving bone mineral density.
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