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논문분류	춘계학술대회 초록집
제목	Association between Renal Dysfunction and General Cognitive Function in Community Dwelling Elderly People: Korean Frailty and Aging Cohort Study
저자	Ji Yoon Kong, Jin Sug Kim, Min Hye Kang, Hyeon Seok Hwang, Shin Yeong Kang, Ri Ra, Kyung Hwan Jeong
출판정보	2020; 2020(1):
키워드	Renal function \| Cognitive function \| older adults \| Cohort study
초록	Cognitive impairment is common in elderly people. Similarly, the prevalence of renal dysfunction is also increased in the elderly. We conducted this study to clarify the relationship between renal function and cognitive impairment in community dwelling elderly people. A cross-sectional analysis was performed on the data of Korean Frailty and Aging Cohort Study (KFACS). Total 2847 participants (1333 men, 1514 women, and age 76.0±3.90 years) who completed baseline assessments were enrolled. The estimated glomerular filtration rate (eGFR, mL/min/1.73m2) was calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Renal function of the participants was classified into four groups by eGFR quartile. General cognitive function was accessed with mini-mental state exam in the Korean version (MMSE-KC). Participants who had MMSE-KC score less than 1.5 standard deviation by age, gender, and education level were regarded as the cognitive impairment. The mean eGFR in quartile 1 was 91.7 ± 3.22 ml/min/1.73m2, and 84.9 ± 1.81 in quartile 2, 76.1 ± 3.66 in quartile 3, and 57.2 ± 10.75 in quartile 4. And the prevalence of cognitive impairment was 10.8% in quartile 1, 15.9% in quartile 2, 15.2% in quartile 3, 14.9% in quartile 4. After multiple adjustment, participants with lower eGFR had lower cognitive function scores on most quartiles (p=0.007). In a simple regression analysis, eGFR was positively correlated with MMSE-KC (r=0.056, P=0.003), memory (r=0.137, P<0.001), recall (r=0.151, P<0.001), and recognition scores (r=0.087, P<0.001). And in multiple linear regression analysis, eGFR was still significantly correlated MMSE-KC (r=0.071, P<0.001), memory (r=0.147, P<0.001), recall (r=0.153, P<0.001), and recognition scores (r=0.088, P<0.001). Renal dysfunction was associated with lower global cognitive function in elderly people. These results suggest that decline of kidney function is a risk factor of cognitive decline in the elderly.
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