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논문분류	춘계학술대회 초록집
제목	Mortality prediction of serum neutrophil gelatinase-associated lipocalin in patients requiring continuous renal replacement therapy
저자	Yohan Park, Tae Hyun Ban, Hyung Duk Kim, Eun Jeong Ko, Jongmin Lee, Seok Chan Kim, Cheol Whee Park, Chul Woo Yang, Yong-Soo Kim, Byung Ha Chung
출판정보	2020; 2020(1):
키워드	NGAL \| critical illness \| acute kidney injury \| renal replacement therapy \| mortality
초록	We investigated whether serum neutrophil gelatinase-associated lipocalin (NGAL) can predict mortality in patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT). This study enrolled 169 patients who underwent serum NGAL testing at CRRT initiation from June 2017 to January 2019. The predictive power of serum NGAL level for 28-day mortality was compared to the Acute Physiology and Chronic Health Evaluation-II (APACHE-II) score and Sequential Organ Failure Assessment (SOFA) score via area under the receiver operating characteristic curve (AuROC) value. There were 55 survivors and 114 non-survivors at 28 days post-CRRT initiation. Median serum NGAL level was significantly higher in the non-survivor group than in the survivor group (743.0 vs. 504.0 ng/mL, P=0.003). The AuROC value of serum NGAL level was 0.640, which was lower than APACHE-II score and SOFA score values (0.767 and 0.715, respectively). However, in the low APACHE-II score group (<27.5), AuROC value of serum NGAL was significantly increased (0.698), and it was an independent risk factor for 28 day-mortality (hazard ratio 2.405, 95% confidence interval (1.209-4.783), P=0.012). In patients with AKI requiring CRRT, serum NGAL levels may be useful for predicting short-term mortality in those with low APACHE-II scores.
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